How Much Does Amitiza Cost? — Save Up to 71% in the US

Our most recent US pharmacy data shows a low of roughly $34.73 for Lubiprostone with a standard discount card. That figure moves with dosage and quantity — check the comparison table for the exact combination you need.

Yes — Cost Plus Drugs lists Lubiprostone at roughly $0.170 per unit, a published price with no membership card or coupon involved. See the three-price comparison above for how that stacks up against discount-card pharmacies.

We found Canadian pricing for Lubiprostone starting near $0.590 per tablet in USD terms. That's before any shipping charge, which the table above breaks out separately.

Drug pricing is set separately in each country through different negotiation, regulatory, and distribution systems, so the same medication can legitimately carry different price tags on either side of the border. In this case, our data shows the US price is actually the lower of the two once a program like Cost Plus Drugs is factored in — the assumption that Canada is always cheaper doesn't hold for every drug.

Amitiza (lubiprostone) is a prescription medication classified as a chloride channel activator. It is approved to treat chronic idiopathic constipation and opioid-induced constipation in adults, and irritable bowel syndrome with constipation in adult women. Unlike laxatives, it works locally in the intestines to increase fluid secretion, which softens stool and promotes bowel movements. It is taken orally as a capsule, typically twice daily with food and water, and must be swallowed whole. Patients with known or suspected bowel obstruction, severe diarrhea, or significant liver disease should consult their doctor before use, as dosage adjustments or alternative treatments may be necessary.

Common side effects of Amitiza include nausea, diarrhea, abdominal pain, bloating, gas, and indigestion. Less frequently, patients may experience headache, dizziness, fatigue, back or joint pain, swelling, runny nose, or sore throat. While serious allergic reactions are uncommon, seek immediate medical attention for symptoms like hives, difficulty breathing, or swelling of the face, lips, tongue, or throat. It's important to discuss your full medical history with your healthcare provider, especially if you have a bowel blockage, active severe diarrhea, or liver problems, to ensure safe use.

Amitiza can interact with various medications. You should provide your doctor or pharmacist with a complete list of all prescription drugs, over-the-counter products, vitamins, and supplements you are taking. Known interactions can occur with certain blood pressure medications, diuretics (water pills), opioid pain relievers like methadone, some prostate medications, and tricyclic antidepressants. This is not a complete list, so a professional medication review is essential before starting treatment.