US pharmacy pricing
Santyl Prices at US Pharmacies
Lowest price found · US pharmacies
$328.01/fill
for Santyl, across the pharmacies in our data
US pharmacy prices — 30gm of 250unit/gm
| Pharmacy | Discount-card price | Regular cash price | Average retail |
|---|---|---|---|
 Kroger Pharmacy | $328.01Lowest | $331.01 | $451.71 |
 Harris Teeter Pharmacy | $328.01Lowest | $331.01 | $451.71 |
 Walgreens | $345.76 | $348.76 | $451.71 |
 Food Lion | $348.01 | $348.01 | $451.71 |
 Publix | $349.01 | $352.01 | $451.71 |
 Walmart Neighborhood Market | $352.52 | $355.52 | $451.71 |
 Walmart Pharmacy | $352.52 | $355.52 | $451.71 |
 Costco | $354.01 | $357.01 | $451.71 |
 CVS Pharmacy | $359.07 | $362.07 | $451.71 |
"Discount-card price" reflects a standard prescription discount card, not insurance. Prices change often — confirm at the pharmacy before filling.
Interchangeable forms
Per RxNorm (U.S. National Library of Medicine), these share the same active ingredient and strength as Santyl.
Frequently asked questions
Is Santyl (Santyl) expensive if I don't have insurance?
At the US pharmacies in our data, the lowest listed discount-card price for Santyl is around $328.01. Prices vary by pharmacy, dosage, and pack size, so use the table above to compare specific options near you.
Is a generic version of Santyl available?
Generic and brand-name pricing for Santyl is broken out in the tables above where both exist in our data. Generic versions are typically the lower-cost option, but availability depends on the specific formulation and dosage.
Is a generic form of Santyl available?
Santyl is the brand name for the drug whose active ingredient is collagenase. While collagenase topical is the generic name, an FDA-approved generic equivalent for Santyl is not currently on the market in the U.S.
What is Santyl and what is it used for?
Santyl is a prescription topical ointment used to help clean wounds by removing dead tissue, a process known as debridement. It is indicated for serious wounds like severe burns and skin ulcers. Dead tissue can harbor bacteria and slow healing. Santyl contains the enzyme collagenase, which breaks down collagen—a key protein in connective tissue—in the non-living tissue. This helps prepare the wound bed for healing. It is important to consult your healthcare provider to determine if Santyl is appropriate for your condition, especially if you are pregnant or breastfeeding. Always seek medical advice if your wound does not improve.
What are the potential side effects of Santyl?
Common side effects of Santyl are typically localized to the application site and may include a burning or painful sensation, temporary redness, and irritation. A rare but serious potential complication of wound debridement is sepsis, a life-threatening bloodstream infection. Symptoms of sepsis can include fever, chills, rapid breathing, and severe weakness. If you experience any of these symptoms or other concerning changes in your health, contact your healthcare provider immediately. You can also report side effects directly to the FDA at 1-800-FDA-1088.