US pharmacy pricing
Where to Find the Cheapest Activella Price
Lowest price found · US pharmacies
$28.55/fill
for Estradiol-Norethindrone Acet, across the pharmacies in our data
US pharmacy prices — 1 package (28 tablets), 1-0.5mg
| Pharmacy | Discount-card price | Regular cash price | Average retail |
|---|---|---|---|
 CVS Pharmacy | $28.55Lowest | $31.55 | $5.99 |
 Kroger Pharmacy | $29.23 | $32.23 | $5.99 |
 Harris Teeter Pharmacy | $29.23 | $32.23 | $5.99 |
 Food Lion | $29.56 | $29.56 | $5.99 |
 Walmart Neighborhood Market | $33.56 | $36.56 | $5.99 |
 Walmart Pharmacy | $33.56 | $36.56 | $5.99 |
 Costco | $35.00 | $35.00 | $5.99 |
 Publix | $36.65 | $36.65 | $5.99 |
 Walgreens | $50.90 | $53.90 | $5.99 |
"Discount-card price" reflects a standard prescription discount card, not insurance. Prices change often — confirm at the pharmacy before filling.
Interchangeable forms
Per RxNorm (U.S. National Library of Medicine), these share the same active ingredient and strength as Estradiol-Norethindrone Acet.
Frequently asked questions
Is Estradiol-Norethindrone Acet (Activella) expensive if I don't have insurance?
At the US pharmacies in our data, the lowest listed discount-card price for Estradiol-Norethindrone Acet is around $28.55. Prices vary by pharmacy, dosage, and pack size, so use the table above to compare specific options near you.
Is a generic version of Estradiol-Norethindrone Acet available?
Generic and brand-name pricing for Estradiol-Norethindrone Acet is broken out in the tables above where both exist in our data. Generic versions are typically the lower-cost option, but availability depends on the specific formulation and dosage.
Is a generic form of Activella available?
Yes, Activella is the brand-name version manufactured by Novo Nordisk. The generic equivalent is called estradiol-norethindrone, which contains the same active ingredients and is commercially available.
What is Activella, and what is it used for?
Activella is a combination hormone therapy medication containing estradiol (an estrogen) and norethindrone (a progestin). It is prescribed to relieve common symptoms of menopause, such as hot flashes, night sweats, and vaginal dryness or discomfort. Additionally, it may be used to help prevent osteoporosis in postmenopausal women at risk of bone loss. The progestin component, norethindrone, is included to reduce the risk of uterine cancer that can be associated with estrogen use alone. This medication is not suitable for everyone. You should not take Activella if you have a history of certain cancers (like breast or uterine cancer), blood clots, stroke, heart attack, liver disease, unexplained vaginal bleeding, or if you have had a hysterectomy. Always discuss your full medical history with your doctor to determine if this treatment is appropriate for you.
What side effects are commonly associated with Activella?
Some patients taking Activella may experience side effects such as headaches, body aches, unusual tiredness, vaginal itching or discharge, non-menstrual vaginal bleeding, discomfort during intercourse, or cold-like symptoms. Difficulty breathing, chills, or fever are also possible. This list is not exhaustive, and other reactions may occur. It is important to discuss the potential benefits and risks with your healthcare provider. If you experience any severe or unexpected side effects while using this medication, you should contact your doctor and consider reporting them to the FDA's MedWatch program.