Full price comparison · US & Canada

How Much Does Ampyra Cost? — Save Up to 67% in the US

Brand availableRx requiredAvailable US & Canadatablet extended release 12 hour

Cheaper in the US

0%

lower price for Dalfampridine Er, based on the lowest comparable per-unit prices we found

US · discount card

$28.77

per fill

Lowest listed pharmacy price

Lowest

US · Cost Plus Drugs

$0.166

per unit

Published price, no card needed

Canada

$0.500

per tablet

Lowest listed pharmacy price

Fetching live USD → CAD rate…

US pharmacy prices — 10mg

PharmacyDiscount-card priceRegular cash priceAverage retail
Walgreens$28.77Lowest$31.77$27.59
Food Lion$66.80$66.80$75.08
Walmart Neighborhood Market$68.14$71.14$75.08
Walmart Pharmacy$68.14$71.14$75.08
Kroger Pharmacy$229.27$232.27$75.08
Harris Teeter Pharmacy$229.27$232.27$75.08
Costco$499.99$499.99$75.08
Publix$1,434.46$1,437.46$75.08

"Discount-card price" reflects a standard prescription discount card, not insurance. Prices change often — confirm at the pharmacy before filling.

Canadian pharmacy prices

Initial · Defaultfrom $30.00
PharmacyPrice / tabletPack sizeShippingTotal
RxOutreach.org$0.50060$0.00$30.00Lowest
Generic · Defaultfrom $30.00
PharmacyPrice / tabletPack sizeShippingTotal
RxOutreach.org$0.50060$0.00$30.00Lowest
Brand · Defaultfrom $30.00
PharmacyPrice / tabletPack sizeShippingTotal
RxOutreach.org$0.50060$0.00$30.00Lowest

Canadian prices are converted to USD at the time of listing and shown before any duties. Shipping and delivery times vary by pharmacy.

Interchangeable forms

Per RxNorm (U.S. National Library of Medicine), these share the same active ingredient and strength as Dalfampridine Er.

Other brand names
Ampyra
Generic clinical forms
12 HR dalfampridine 10 MG Extended Release Oral Tablet

Frequently asked questions

How much does Dalfampridine Er (Ampyra) cost without insurance?

Our most recent US pharmacy data shows a low of roughly $28.77 for Dalfampridine Er with a standard discount card. That figure moves with dosage and quantity — check the comparison table for the exact combination you need.

Is Dalfampridine Er (Ampyra) available through Cost Plus Drugs?

Yes — Cost Plus Drugs lists Dalfampridine Er at roughly $0.166 per unit, a published price with no membership card or coupon involved. See the three-price comparison above for how that stacks up against discount-card pharmacies.

What do Canadian pharmacies charge for Dalfampridine Er (Ampyra)?

We found Canadian pricing for Dalfampridine Er starting near $0.500 per tablet in USD terms. That's before any shipping charge, which the table above breaks out separately.

Why is Dalfampridine Er (Ampyra) priced differently in the US and Canada?

Drug pricing is set separately in each country through different negotiation, regulatory, and distribution systems, so the same medication can legitimately carry different price tags on either side of the border. In this case, our data shows the US price is actually the lower of the two once a program like Cost Plus Drugs is factored in — the assumption that Canada is always cheaper doesn't hold for every drug.

How much does Ampyra cost with insurance?

The out-of-pocket cost for Ampyra with insurance depends on your specific plan's details, including copays and deductibles. It is often beneficial to compare your insurance copay to discounted prices available through pharmacy savings programs, as you may find a lower cost outside of your insurance coverage.

Is there a generic of Ampyra?

Yes, the generic name for Ampyra is dalfampridine. It is manufactured by several companies, including Aurobindo, Sun Pharmaceutical, Mylan, and West-Ward Pharmaceuticals. Generic medications typically offer substantial cost savings. You can search for savings coupons or discount programs for dalfampridine.

What is Ampyra?

Ampyra (dalfampridine) is an extended-release tablet prescription medication used to improve walking in individuals with multiple sclerosis (MS). It is the only FDA-approved drug specifically for this purpose. MS damages the protective myelin sheath around nerve cells, which can disrupt the electrical signals needed for muscle movement, particularly in the legs. Ampyra works by blocking potassium channels on the surface of damaged nerves. This blocking action helps the nerves maintain an electrical signal long enough to successfully transmit it to the leg muscles. It is typically taken as one tablet twice daily.