US pharmacy pricing
Where to Find the Cheapest Depo-Estradiol Price
Lowest price found · US pharmacies
$266.88/fill
for Depo-Estradiol, across the pharmacies in our data
US pharmacy prices — 5ml of 5mg/ml
| Pharmacy | Discount-card price | Regular cash price | Average retail |
|---|---|---|---|
 Kroger Pharmacy | $266.88Lowest | $269.88 | $5.77 |
 Harris Teeter Pharmacy | $266.88Lowest | $269.88 | $5.77 |
 Walgreens | $281.63 | $284.63 | $5.77 |
 Food Lion | $284.26 | $284.26 | $5.77 |
 Publix | $284.51 | $287.51 | $5.77 |
 Walmart Neighborhood Market | $286.89 | $289.89 | $5.77 |
 Walmart Pharmacy | $286.89 | $289.89 | $5.77 |
 Costco | $288.01 | $291.01 | $5.77 |
 CVS Pharmacy | $295.74 | $298.74 | $5.77 |
"Discount-card price" reflects a standard prescription discount card, not insurance. Prices change often — confirm at the pharmacy before filling.
Interchangeable forms
Per RxNorm (U.S. National Library of Medicine), these share the same active ingredient and strength as Depo-Estradiol.
Frequently asked questions
Is Depo-Estradiol (Depo-Estradiol) expensive if I don't have insurance?
Our most recent US pharmacy data shows a low of roughly $266.88 for Depo-Estradiol with a standard discount card. That figure moves with dosage and quantity — check the comparison table for the exact combination you need.
Does Depo-Estradiol have a generic equivalent?
Generic and brand-name pricing for Depo-Estradiol is broken out in the tables above where both exist in our data. Generic versions are typically the lower-cost option, but availability depends on the specific formulation and dosage.
Is a generic version of Depo-Estradiol available?
Depo-Estradiol is the brand name for an injectable form of estradiol cypionate. While estradiol cypionate is the generic drug name, a branded generic or alternative injectable product may not be widely available. Patients should consult their pharmacist or healthcare provider to inquire about the current availability of generic alternatives for this specific formulation.
What is Depo-Estradiol and what is it used for?
Depo-Estradiol is a prescription estrogen therapy given as an intramuscular injection. Its active component, estradiol cypionate, helps manage moderate to severe vasomotor symptoms associated with menopause, including hot flashes and night sweats. It is also approved for treating estrogen deficiency. Additionally, it is sometimes prescribed off-label as part of feminizing hormone therapy for transgender women. A healthcare professional administers the injection, typically once every three to four weeks. The appropriate dosage varies based on individual medical needs and should be determined by a doctor.
What are the potential side effects of Depo-Estradiol?
Common side effects of Depo-Estradiol include headaches, abdominal bloating or cramps, breast tenderness, nausea, and irregular vaginal bleeding or spotting. Other possible effects are fluid retention, elevated blood pressure or blood sugar, liver issues, vaginal yeast infections, and hair loss. Serious risks include an increased chance of blood clots, stroke, heart attack, and breast cancer. Postmenopausal women aged 65 and older may have a heightened risk of dementia. Allergic reactions, though rare, can occur and require immediate medical attention. This list is not exhaustive. Discuss all potential risks, your medical history, and current medications with your healthcare provider before starting treatment.