Adapalene (Adapalene) Rx Price Comparison: US vs Canada — Save Up to 95% in Canada

At the US pharmacies in our data, the lowest listed discount-card price for Adapalene is around $34.42. Prices vary by pharmacy, dosage, and pack size, so use the table above to compare specific options near you.

Yes — Cost Plus Drugs lists Adapalene at roughly $10.06 per unit, a published price with no membership card or coupon involved. See the three-price comparison above for how that stacks up against discount-card pharmacies.

Canadian pharmacy listings in our data show Adapalene priced from about $0.500 per tablet (converted to USD), before shipping. Pack size and pharmacy both affect the final total — see the Canada pricing table for specifics.

Drug pricing is set separately in each country through different negotiation, regulatory, and distribution systems, so the same medication can legitimately carry different price tags on either side of the border. In this case, our data shows the Canadian price coming in lower — but that isn't true for every drug, so it's worth checking each medication individually rather than assuming.

Adapalene may be covered under Medicare Part D or Medicare Advantage plans, but coverage is not guaranteed and depends on your plan's formulary. If covered, copays can range considerably. Even with Medicare, it's worth comparing your plan's cost to the price available with a pharmacy savings card or program, as the discounted cash price could potentially offer greater savings than your Medicare copay.

Adapalene is the generic name for the medication. The most common brand-name version is Differin.

Adapalene is a topical retinoid medication FDA-approved for treating mild to moderate acne. It works by reducing the number and severity of acne lesions, decreasing inflammation, and promoting skin cell turnover. It is typically applied once daily in the evening to clean, dry skin, avoiding the eyes, mouth, and areas with open wounds or severe irritation. It is intended for use by individuals 12 years and older. Acne may temporarily appear worse when treatment begins. Using more than prescribed will not improve results and can increase skin irritation. Always follow the instructions provided by your healthcare provider and discuss use with your doctor if you are pregnant, breastfeeding, or have specific skin concerns.