Duloxetine Hcl (Duloxetine Hcl) Rx Price Comparison: US vs Canada — Save Up to 91% in the US

At the US pharmacies in our data, the lowest listed discount-card price for Duloxetine Hcl is around $8.17. Prices vary by pharmacy, dosage, and pack size, so use the table above to compare specific options near you.

Yes — Cost Plus Drugs lists Duloxetine Hcl at roughly $0.026 per unit, a published price with no membership card or coupon involved. See the three-price comparison above for how that stacks up against discount-card pharmacies.

Canadian pharmacy listings in our data show Duloxetine Hcl priced from about $0.280 per tablet (converted to USD), before shipping. Pack size and pharmacy both affect the final total — see the Canada pricing table for specifics.

Drug pricing is set separately in each country through different negotiation, regulatory, and distribution systems, so the same medication can legitimately carry different price tags on either side of the border. In this case, our data shows the US price is actually the lower of the two once a program like Cost Plus Drugs is factored in — the assumption that Canada is always cheaper doesn't hold for every drug.

Most health insurance plans include duloxetine on their formulary, but your specific cost will depend on your plan's copay, deductible, and coinsurance requirements. It's advisable to check with your insurer or pharmacist for your exact out-of-pocket amount. It can also be worthwhile to compare this cost with the discounted price available through a pharmacy savings program, as it may sometimes be the more affordable option.

The medication is available under the brand names Cymbalta and Drizalma Sprinkle. These brand-name products are typically more expensive than the generic. Savings programs can offer substantial discounts on both brand-name and generic medications.

Within the same drug class (SNRIs), alternatives like venlafaxine may have a similar or lower cost and comparable effects and side effects. For treating depression or anxiety, other classes of antidepressants can be significantly less expensive. Tricyclic antidepressants (e.g., amitriptyline) are often the lowest-cost generic options, while certain SSRIs (e.g., fluoxetine) are also generally much cheaper than duloxetine. The most appropriate alternative depends on your specific health condition, so discussing all options with your healthcare provider is essential.