Advair Diskus (Fluticasone-Salmeterol) Rx Price Comparison: US vs Canada — Save Up to 100% in Canada

Our most recent US pharmacy data shows a low of roughly $57.04 for Fluticasone-Salmeterol with a standard discount card. That figure moves with dosage and quantity — check the comparison table for the exact combination you need.

Yes — Cost Plus Drugs lists Fluticasone-Salmeterol at roughly $78.00 per unit, a published price with no membership card or coupon involved. See the three-price comparison above for how that stacks up against discount-card pharmacies.

We found Canadian pricing for Fluticasone-Salmeterol starting near $0.100 per tablet in USD terms. That's before any shipping charge, which the table above breaks out separately.

Drug pricing is set separately in each country through different negotiation, regulatory, and distribution systems, so the same medication can legitimately carry different price tags on either side of the border. In this case, our data shows the Canadian price coming in lower — but that isn't true for every drug, so it's worth checking each medication individually rather than assuming.

Advair Diskus is an FDA-approved inhaler containing a combination of two medications: fluticasone propionate, an anti-inflammatory corticosteroid, and salmeterol, a long-acting bronchodilator. It is prescribed for the daily maintenance treatment of asthma and COPD, including chronic bronchitis and emphysema, in adults and children aged four and older. By working together, these drugs help control and prevent symptoms like wheezing and shortness of breath. It's important to understand that Advair Diskus is not intended for the immediate relief of an acute asthma attack; it is a controller medication used regularly to manage chronic symptoms. Patients should follow their healthcare provider's specific instructions regarding dosing, which is typically twice daily.

Advair Diskus can cause side effects ranging from common to serious. Frequently reported ones include headache, throat irritation, hoarseness, cough, upper respiratory infections, and nausea. More serious potential effects include oral fungal infections (thrush), increased risk of infections, adrenal insufficiency, eye problems such as glaucoma or cataracts, and slowed growth in children. In rare cases, it can worsen breathing problems or cause severe allergic reactions, characterized by hives, facial swelling, or difficulty breathing, which require immediate medical attention. Patients should contact their healthcare provider if any side effects persist or worsen and discuss all potential risks before starting treatment.

Several medications can interact with Advair Diskus. Because its components are metabolized by the liver enzyme CYP3A4, strong inhibitors of this enzyme—such as certain antifungals (e.g., ketoconazole) and antibiotics (e.g., clarithromycin)—can increase blood levels of the drug and raise the risk of side effects. Use with monoamine oxidase inhibitors (MAOIs) or tricyclic antidepressants also requires caution, as they can increase the cardiovascular effects of salmeterol. Beta-blockers may reduce the effectiveness of the long-acting bronchodilator in Advair and are generally avoided in patients with asthma or COPD. Non-potassium-sparing diuretics may worsen low potassium levels, a potential side effect of Advair. Always provide your doctor and pharmacist with a complete list of all medications and supplements you are taking.