How Much Does Isosorbide Dinitrate Cost? — Save Up to 62% in the US

Our most recent US pharmacy data shows a low of roughly $22.40 for Isosorbide Dinitrate with a standard discount card. That figure moves with dosage and quantity — check the comparison table for the exact combination you need.

Yes — Cost Plus Drugs lists Isosorbide Dinitrate at roughly $0.050 per unit, a published price with no membership card or coupon involved. See the three-price comparison above for how that stacks up against discount-card pharmacies.

We found Canadian pricing for Isosorbide Dinitrate starting near $0.130 per tablet in USD terms. That's before any shipping charge, which the table above breaks out separately.

Drug pricing is set separately in each country through different negotiation, regulatory, and distribution systems, so the same medication can legitimately carry different price tags on either side of the border. In this case, our data shows the US price is actually the lower of the two once a program like Cost Plus Drugs is factored in — the assumption that Canada is always cheaper doesn't hold for every drug.

Isosorbide dinitrate is the generic name for the active ingredient. A well-known brand-name version of this medication is Isordil. Both the brand-name and generic forms are used to treat coronary artery disease, and using a discount card can help reduce the cost at many local and chain pharmacies.

Isosorbide dinitrate is a preventive medication for angina (chest pain) caused by coronary artery disease, where narrowed heart arteries limit oxygen supply. It is a vasodilator, meaning it relaxes and widens blood vessels to increase blood flow to the heart. It is not a rescue medication for stopping an ongoing angina attack. Typically taken once or twice daily, it provides protection for about 12 hours. A key aspect of its dosing is a daily 'nitrate-free' interval of at least 14 hours to prevent the body from developing tolerance to the drug's effects.

Common side effects include headache, dizziness, lightheadedness, flushing, rapid heartbeat, and nausea. Headaches can be particularly intense when starting the medication but often lessen over time; your doctor can recommend pain relief if needed. Less common but serious side effects include fainting, severe drops in blood pressure, and allergic reactions characterized by rash, swelling, or difficulty breathing.