Full price comparison · US & Canada
Leucovorin Calcium Prices — US Pharmacy Cost vs Canada — Save Up to 98% in the US
Cheaper in the US
0%
lower price for Leucovorin Calcium, based on the lowest comparable per-unit prices we found
US · discount card
$8.51
per fill
Lowest listed pharmacy price
US · Cost Plus Drugs
$0.155
per unit
Published price, no card needed
Canada
$9.80
per tablet
Lowest listed pharmacy price
US pharmacy prices — 5mg
| Pharmacy | Discount-card price | Regular cash price | Average retail |
|---|---|---|---|
 Kroger Pharmacy | $8.51Lowest | $11.51 | $1.50 |
 Harris Teeter Pharmacy | $8.51Lowest | $11.51 | $1.50 |
 Food Lion | $14.60 | $14.60 | $1.50 |
 Costco | $15.99 | $15.99 | $1.50 |
 Publix | $21.41 | $24.41 | $1.50 |
 Walgreens | $29.07 | $32.07 | $1.50 |
 CVS Pharmacy | $31.99 | $34.99 | $1.50 |
"Discount-card price" reflects a standard prescription discount card, not insurance. Prices change often — confirm at the pharmacy before filling.
Canadian pharmacy prices
Initial · 15 mg
| Pharmacy | Price / tablet | Pack size | Shipping | Total |
|---|---|---|---|---|
 LifeRxPharmacy.com | $9.80 | 30 | $14.95 | $293.89Lowest |
 OffShoreCheapMeds.com | $10.53 | 30 | $14.95 | $316.01 |
| $11.69 | 30 | $14.95 | $350.83 | |
| LifeRxPharmacy.com | $11.76 | 20 | $14.95 | $235.11 |
| OffShoreCheapMeds.com | $12.64 | 20 | $14.95 | $252.81 |
| $14.03 | 20 | $14.95 | $280.66 | |
 GoldStarMeds.com | $19.55 | 10 | $0.00 | $195.45 |
 1800RxOnline.com | $21.72 | 10 | $0.00 | $217.17 |
Canadian prices are converted to USD at the time of listing and shown before any duties. Shipping and delivery times vary by pharmacy.
Interchangeable forms
Per RxNorm (U.S. National Library of Medicine), these share the same active ingredient and strength as Leucovorin Calcium.
Frequently asked questions
Is Leucovorin Calcium (Leucovorin Calcium) expensive if I don't have insurance?
Our most recent US pharmacy data shows a low of roughly $8.51 for Leucovorin Calcium with a standard discount card. That figure moves with dosage and quantity — check the comparison table for the exact combination you need.
Is Leucovorin Calcium (Leucovorin Calcium) available through Cost Plus Drugs?
Yes — Cost Plus Drugs lists Leucovorin Calcium at roughly $0.155 per unit, a published price with no membership card or coupon involved. See the three-price comparison above for how that stacks up against discount-card pharmacies.
What do Canadian pharmacies charge for Leucovorin Calcium (Leucovorin Calcium)?
We found Canadian pricing for Leucovorin Calcium starting near $9.80 per tablet in USD terms. That's before any shipping charge, which the table above breaks out separately.
Why is Leucovorin Calcium (Leucovorin Calcium) priced differently in the US and Canada?
Drug pricing is set separately in each country through different negotiation, regulatory, and distribution systems, so the same medication can legitimately carry different price tags on either side of the border. In this case, our data shows the US price is actually the lower of the two once a program like Cost Plus Drugs is factored in — the assumption that Canada is always cheaper doesn't hold for every drug.
Is Leucovorin covered by Medicare?
Most Medicare Part D and Medicare Advantage plans provide coverage for Leucovorin. Your exact copay or coinsurance amount will vary based on your plan's details, including whether you have met your deductible. To ensure you are getting the lowest available price, compare your plan's cost against the discounted rate offered by pharmacy savings programs before your purchase.
Are there any brand-name versions of Leucovorin available?
The brand-name product Wellcovorin was discontinued by its manufacturer in early 2026. Today, Leucovorin is only available as a generic medication from multiple manufacturers.
Can I use a cheaper over-the-counter product instead of Leucovorin?
For its primary uses in cancer treatment or methotrexate toxicity, there is no safe over-the-counter substitute for Leucovorin. While standard folic acid supplements are inexpensive and effective for treating simple nutritional deficiencies, they are not interchangeable with Leucovorin in an oncology setting. Chemotherapy drugs like methotrexate block a key enzyme that folic acid requires. Only Leucovorin can bypass this block. Substituting an OTC supplement in these situations can lead to severe, life-threatening toxicity and must never be done without explicit guidance from your oncologist.