Full price comparison · US & Canada
How Much Does Depo-Medrol Cost? — Save Up to 48% in the US
Cheaper in the US
0%
lower price for Methylprednisolone Acetate, based on the lowest comparable per-unit prices we found
US · discount card
$12.41
per fill
Lowest listed pharmacy price
US · Cost Plus Drugs
$0.098
per unit
Published price, no card needed
Canada
$0.190
per tablet
Lowest listed pharmacy price
US pharmacy prices — 1ml of 40mg/ml
| Pharmacy | Discount-card price | Regular cash price | Average retail |
|---|---|---|---|
 Kroger Pharmacy | $12.41Lowest | $15.41 | $22.87 |
 Harris Teeter Pharmacy | $12.41Lowest | $15.41 | $22.87 |
 Walmart Neighborhood Market | $13.26 | $16.26 | $22.87 |
 Walmart Pharmacy | $13.26 | $16.26 | $22.87 |
 CVS Pharmacy | $13.52 | $16.52 | $22.87 |
 Publix | $17.17 | $20.17 | $22.87 |
 Walgreens | $23.62 | $26.62 | $22.87 |
"Discount-card price" reflects a standard prescription discount card, not insurance. Prices change often — confirm at the pharmacy before filling.
Canadian pharmacy prices
Initial · 4 mgfrom $16.42
| Pharmacy | Price / tablet | Pack size | Shipping | Total |
|---|---|---|---|---|
 CanadianPharmacyAdvantage.com | $0.210 | 100 | Free | $20.51Lowest |
 LifeRxPharmacy.com | $0.230 | 90 | $14.95 | $20.53 |
 OffShoreCheapMeds.com | $0.250 | 90 | $14.95 | $22.08 |
| LifeRxPharmacy.com | $0.270 | 60 | $14.95 | $16.42 |
| $0.280 | 90 | $14.95 | $24.95 | |
| OffShoreCheapMeds.com | $0.290 | 60 | $14.95 | $17.66 |
 CanadaPharmacies.com | $0.320 | 100 | Free | $31.99 |
 CanadianPrescriptionDrugstore.com | $0.330 | 100 | $14.95 | $33.00 |
| $0.330 | 60 | $14.95 | $19.95 | |
 CanadaPharmacyPro.com | $0.520 | 90 | $14.95 | $46.62 |
| CanadaPharmacyPro.com | $0.550 | 60 | $14.95 | $32.91 |
 GoldStarMeds.com | $0.660 | 30 | $0.00 | $19.66 |
 1800RxOnline.com | $0.730 | 30 | $0.00 | $21.84 |
 SPFPharmacy.com | $0.940 | 100 | $9.95 | $93.61 |
| GoldStarMeds.com | $0.980 | — | $0.00 | $97.63 |
| 1800RxOnline.com | $1.08 | — | $0.00 | $108.48 |
 InhalersOnline.com | $1.11 | 100 | $0.00 | $110.94 |
Initial · 8 mgfrom $12.76
| Pharmacy | Price / tablet | Pack size | Shipping | Total |
|---|---|---|---|---|
| LifeRxPharmacy.com | $0.470 | 84 | $14.95 | $39.39Lowest |
| OffShoreCheapMeds.com | $0.500 | 84 | $14.95 | $42.36 |
| LifeRxPharmacy.com | $0.560 | 56 | $14.95 | $31.51 |
| OffShoreCheapMeds.com | $0.610 | 56 | $14.95 | $33.88 |
| $0.680 | 84 | $14.95 | $57.21 | |
| GoldStarMeds.com | $0.700 | 28 | $0.00 | $19.52 |
| 1800RxOnline.com | $0.770 | 28 | $0.00 | $21.69 |
| $0.820 | 56 | $14.95 | $45.76 | |
| CanadianPharmacyAdvantage.com | $0.910 | 14 | Free | $12.76 |
| CanadaPharmacies.com | $1.71 | 14 | Free | $23.99 |
Initial · 16 mgfrom $20.46
| Pharmacy | Price / tablet | Pack size | Shipping | Total |
|---|---|---|---|---|
| CanadianPharmacyAdvantage.com | $0.490 | 84 | Free | $40.90Lowest |
| CanadianPrescriptionDrugstore.com | $0.510 | 84 | $14.95 | $43.00 |
| LifeRxPharmacy.com | $0.600 | 84 | $14.95 | $50.10 |
| CanadaPharmacies.com | $0.620 | 84 | Free | $51.99 |
| $0.640 | 84 | $14.95 | $54.13 | |
| OffShoreCheapMeds.com | $0.640 | 84 | $14.95 | $53.87 |
| CanadaPharmacyPro.com | $0.680 | 84 | $14.95 | $57.19 |
| CanadaPharmacyPro.com | $0.720 | 56 | $14.95 | $40.37 |
| LifeRxPharmacy.com | $0.720 | 56 | $14.95 | $40.07 |
| CanadianPharmacyAdvantage.com | $0.730 | 28 | Free | $20.46 |
| $0.770 | 56 | $14.95 | $43.31 | |
| OffShoreCheapMeds.com | $0.770 | 56 | $14.95 | $43.09 |
| GoldStarMeds.com | $0.840 | 28 | $0.00 | $23.43 |
| 1800RxOnline.com | $0.930 | 28 | $0.00 | $26.03 |
| CanadaPharmacies.com | $1.14 | 28 | Free | $31.99 |
| InhalersOnline.com | $1.94 | — | $0.00 | $174.99 |
| SPFPharmacy.com | $1.99 | 100 | $9.95 | $199.45 |
| GoldStarMeds.com | $2.18 | — | $0.00 | $218.00 |
| InhalersOnline.com | $2.26 | 84 | $0.00 | $190.02 |
| 1800RxOnline.com | $2.42 | — | $0.00 | $242.22 |
| InhalersOnline.com | $2.50 | — | $0.00 | $74.99 |
| InhalersOnline.com | $3.57 | 14 | $0.00 | $49.99 |
Generic · 4 mgfrom $12.81
| Pharmacy | Price / tablet | Pack size | Shipping | Total |
|---|---|---|---|---|
| LifeRxPharmacy.com | $0.190 | 90 | $14.95 | $17.47Lowest |
| $0.190 | 90 | $14.95 | $16.77 | |
| LifeRxPharmacy.com | $0.210 | 60 | $14.95 | $12.81 |
| OffShoreCheapMeds.com | $0.210 | 90 | $14.95 | $18.78 |
| CanadianPharmacyAdvantage.com | $0.220 | 100 | Free | $21.77 |
| $0.220 | 60 | $14.95 | $13.41 | |
| OffShoreCheapMeds.com | $0.230 | 60 | $14.95 | $13.77 |
| CanadaPharmacies.com | $0.320 | 100 | Free | $31.99 |
| GoldStarMeds.com | $0.640 | 30 | $0.00 | $19.05 |
| 1800RxOnline.com | $0.710 | 30 | $0.00 | $21.17 |
Generic · 8 mgfrom $20.16
| Pharmacy | Price / tablet | Pack size | Shipping | Total |
|---|---|---|---|---|
| LifeRxPharmacy.com | $0.340 | 90 | $14.95 | $30.40Lowest |
| OffShoreCheapMeds.com | $0.360 | 90 | $14.95 | $32.69 |
| OffShoreCheapMeds.com | $0.440 | 60 | $14.95 | $26.15 |
| LifeRxPharmacy.com | $0.470 | 180 | $14.95 | $83.70 |
| $0.530 | 90 | $14.95 | $47.45 | |
| $0.630 | 60 | $14.95 | $37.96 | |
| GoldStarMeds.com | $0.670 | 30 | $0.00 | $20.16 |
| 1800RxOnline.com | $0.750 | 30 | $0.00 | $22.40 |
Brand · 4 mgfrom $12.81
| Pharmacy | Price / tablet | Pack size | Shipping | Total |
|---|---|---|---|---|
| LifeRxPharmacy.com | $0.190 | 90 | $14.95 | $17.47Lowest |
| $0.190 | 90 | $14.95 | $16.77 | |
| LifeRxPharmacy.com | $0.210 | 60 | $14.95 | $12.81 |
| OffShoreCheapMeds.com | $0.210 | 90 | $14.95 | $18.78 |
| CanadianPharmacyAdvantage.com | $0.220 | 100 | Free | $21.77 |
| $0.220 | 60 | $14.95 | $13.41 | |
| OffShoreCheapMeds.com | $0.230 | 60 | $14.95 | $13.77 |
| CanadaPharmacies.com | $0.320 | 100 | Free | $31.99 |
| GoldStarMeds.com | $0.640 | 30 | $0.00 | $19.05 |
| 1800RxOnline.com | $0.710 | 30 | $0.00 | $21.17 |
Brand · 8 mgfrom $20.16
| Pharmacy | Price / tablet | Pack size | Shipping | Total |
|---|---|---|---|---|
| LifeRxPharmacy.com | $0.340 | 90 | $14.95 | $30.40Lowest |
| OffShoreCheapMeds.com | $0.360 | 90 | $14.95 | $32.69 |
| OffShoreCheapMeds.com | $0.440 | 60 | $14.95 | $26.15 |
| LifeRxPharmacy.com | $0.470 | 180 | $14.95 | $83.70 |
| $0.530 | 90 | $14.95 | $47.45 | |
| $0.630 | 60 | $14.95 | $37.96 | |
| GoldStarMeds.com | $0.670 | 30 | $0.00 | $20.16 |
| 1800RxOnline.com | $0.750 | 30 | $0.00 | $22.40 |
Canadian prices are converted to USD at the time of listing and shown before any duties. Shipping and delivery times vary by pharmacy.
Interchangeable forms
Per RxNorm (U.S. National Library of Medicine), these share the same active ingredient and strength as Methylprednisolone Acetate.
Frequently asked questions
What's the cash price for Methylprednisolone Acetate (Depo-Medrol) in the US?
At the US pharmacies in our data, the lowest listed discount-card price for Methylprednisolone Acetate is around $12.41. Prices vary by pharmacy, dosage, and pack size, so use the table above to compare specific options near you.
Can I buy Methylprednisolone Acetate (Depo-Medrol) at a Cost Plus Drugs price?
Yes — Cost Plus Drugs lists Methylprednisolone Acetate at roughly $0.098 per unit, a published price with no membership card or coupon involved. See the three-price comparison above for how that stacks up against discount-card pharmacies.
How much does Methylprednisolone Acetate (Depo-Medrol) cost in Canada?
Canadian pharmacy listings in our data show Methylprednisolone Acetate priced from about $0.190 per tablet (converted to USD), before shipping. Pack size and pharmacy both affect the final total — see the Canada pricing table for specifics.
Why does Methylprednisolone Acetate (Depo-Medrol) cost more in one country than the other?
Drug pricing is set separately in each country through different negotiation, regulatory, and distribution systems, so the same medication can legitimately carry different price tags on either side of the border. In this case, our data shows the US price is actually the lower of the two once a program like Cost Plus Drugs is factored in — the assumption that Canada is always cheaper doesn't hold for every drug.
How much does Depo-Medrol typically cost with health insurance?
The cost of Depo-Medrol with insurance depends entirely on the specific details of your plan, including your deductible and copay structure, so prices vary widely. In some cases, a pharmacy discount program may offer a lower price than your insurance copay. Your pharmacist can often run a price comparison for you to identify the most affordable payment method.
Is Depo-Medrol covered by Medicare, and what is the cost?
Original Medicare (Part A and Part B) does not typically cover Depo-Medrol when administered in an outpatient clinic setting, though coverage may apply in a hospital. Medicare Part D plans and Medicare Advantage plans with drug coverage are more likely to cover the generic version, methylprednisolone acetate injection. For patients without prescription drug coverage, pharmacy savings programs or coupons can help manage the out-of-pocket expense.
Is a generic version of Depo-Medrol available?
Yes. The active ingredient in Depo-Medrol is methylprednisolone acetate. This generic corticosteroid injection is manufactured by several companies, including Teva, Sandoz, and Amneal Pharmaceuticals.