How Much Does Methotrexate Cost? — Save Up to 85% in the US

Our most recent US pharmacy data shows a low of roughly $13.60 for Methotrexate Sodium with a standard discount card. That figure moves with dosage and quantity — check the comparison table for the exact combination you need.

Yes — Cost Plus Drugs lists Methotrexate Sodium at roughly $0.078 per unit, a published price with no membership card or coupon involved. See the three-price comparison above for how that stacks up against discount-card pharmacies.

We found Canadian pricing for Methotrexate Sodium starting near $0.530 per tablet in USD terms. That's before any shipping charge, which the table above breaks out separately.

Drug pricing is set separately in each country through different negotiation, regulatory, and distribution systems, so the same medication can legitimately carry different price tags on either side of the border. In this case, our data shows the US price is actually the lower of the two once a program like Cost Plus Drugs is factored in — the assumption that Canada is always cheaper doesn't hold for every drug.

Whether a cheaper alternative exists depends largely on the condition being treated. For cancer, treatment is highly individualized, and alternatives are not directly comparable. For autoimmune conditions like rheumatoid arthritis and psoriasis, other conventional disease-modifying antirheumatic drugs (DMARDs) are available. These include generic medications such as azathioprine, cyclosporine, hydroxychloroquine, and leflunomide. Being generics, their prices are often competitive with Methotrexate Sodium. In contrast, biologic DMARDs (like Humira, Enbrel, Simponi, and Xeljanz) are typically far more expensive. Any change in therapy should only be made in consultation with your doctor.

Methotrexate Sodium can cause a range of side effects. Commonly reported ones include nausea, vomiting, diarrhea, mouth sores, hair loss, and skin reactions. It can also affect bone marrow, leading to low blood cell counts, and may cause liver problems. Because it lowers folate levels, patients are often advised to take a folic acid supplement. More serious side effects that require prompt medical attention include signs of liver damage (like dark urine), easy bruising or bleeding, fever, swollen glands, severe weakness, or symptoms of a severe allergic reaction (such as trouble breathing or swallowing). Methotrexate is contraindicated in pregnancy due to risk of fetal harm and can affect sperm production in males; patients planning a family should discuss this with their healthcare provider. This is not a complete list, so always consult your doctor or pharmacist for medical advice specific to your situation.