How Much Does Naloxone Hcl Cost? — Save Up to 41% in the US

At the US pharmacies in our data, the lowest listed discount-card price for Naloxone Hcl is around $26.51. Prices vary by pharmacy, dosage, and pack size, so use the table above to compare specific options near you.

Yes — Cost Plus Drugs lists Naloxone Hcl at roughly $49.01 per unit, a published price with no membership card or coupon involved. See the three-price comparison above for how that stacks up against discount-card pharmacies.

Canadian pharmacy listings in our data show Naloxone Hcl priced from about $82.50 per tablet (converted to USD), before shipping. Pack size and pharmacy both affect the final total — see the Canada pricing table for specifics.

Drug pricing is set separately in each country through different negotiation, regulatory, and distribution systems, so the same medication can legitimately carry different price tags on either side of the border. In this case, our data shows the US price is actually the lower of the two once a program like Cost Plus Drugs is factored in — the assumption that Canada is always cheaper doesn't hold for every drug.

Naloxone is available as a generic drug produced by several manufacturers, including Akorn and Mylan. It is also the active ingredient in the brand-name overdose reversal medications Narcan and Evzio. Information on obtaining these medications, including potential savings options, is widely available from pharmacies and other health resources.

Naloxone is a generic prescription drug used as an emergency treatment to reverse the life-threatening depression of the central nervous system caused by an opioid overdose. Opioids work by binding to specific receptors in the brain and nervous system, which can slow breathing to a dangerous halt during an overdose. Naloxone acts by displacing opioids from these same receptors, rapidly restoring normal respiratory function without activating the receptors itself. It can be administered via intramuscular or intravenous injection, subcutaneous injection, or as a nasal spray, with effects typically beginning within three to five minutes. It is often packaged in emergency kits designed for use by both medical professionals and laypersons, which may include items like syringes and a breathing barrier. Beyond overdose reversal, naloxone is sometimes used diagnostically and is also a component of Suboxone, a medication for opioid dependence, where it helps deter misuse of the opioid buprenorphine.

The most frequent side effects of naloxone result from the sudden reversal of opioid effects and can resemble symptoms of opioid withdrawal. These may include nausea, vomiting, sweating, flushing, rapid heart rate, and changes in blood pressure. If administered to a patient dependent on opioids for pain control, it can trigger the abrupt return of severe pain. More serious, though less common, potential effects include seizures, cardiac events, coma, or death. Psychological effects like agitation or hallucinations are possible, and allergic reactions, while rare, can occur.