How Much Does Odefsey Cost?

At the US pharmacies in our data, the lowest listed discount-card price for Odefsey is around $3,909.09. Prices vary by pharmacy, dosage, and pack size, so use the table above to compare specific options near you.

Canadian pharmacy listings in our data show Odefsey priced from about $51.34 per tablet (converted to USD), before shipping. Pack size and pharmacy both affect the final total — see the Canada pricing table for specifics.

Drug pricing is set separately in each country through different negotiation, regulatory, and distribution systems, so the same medication can legitimately carry different price tags on either side of the border. Check the comparison table above for the specific numbers on Odefsey.

Generic and brand-name pricing for Odefsey is broken out in the tables above where both exist in our data. Generic versions are typically the lower-cost option, but availability depends on the specific formulation and dosage.

No, Odefsey is only available as a brand-name medication. There is currently no FDA-approved generic equivalent on the market in the United States.

Odefsey is a combination antiretroviral tablet containing emtricitabine, rilpivirine, and tenofovir alafenamide. It is prescribed for the treatment of HIV-1 infection in patients who are at least 12 years old and weigh 77 pounds (35 kg) or more. It is not a cure for HIV or AIDS. Important considerations before use include disclosing your full medical history—especially regarding hepatitis B or C, liver or kidney issues, mental health conditions like depression, and pregnancy status—as well as providing a complete list of all other medications and supplements. Odefsey has significant drug interactions; it should not be taken with certain anticonvulsants, the steroid dexamethasone, St. John's wort, specific proton pump inhibitors, or rifampin/rifapentine. The medication is taken once daily with food, exactly as prescribed. Do not adjust your dose or stop taking it without consulting your doctor, as doing so can cause the virus to rebound and potentially develop resistance to treatment.

All patients receive a Medication Guide with each prescription fill, which should be reviewed carefully. Common side effects include headache, insomnia (trouble sleeping), and nausea. More serious effects can involve mood changes, body fat redistribution, kidney or bone problems, and immune system changes. Seek immediate medical attention for symptoms like severe rash, fever, skin blisters, difficulty breathing, eye redness or swelling, or dark-colored urine. Patients with hepatitis B or C may experience changes in liver enzymes. Odefsey carries a boxed warning, the FDA's strongest, regarding the risk of severe hepatitis B flare-ups in co-infected patients if treatment containing emtricitabine and/or tenofovir is discontinued. Liver function requires close monitoring in these individuals. This is not an exhaustive list. For a complete overview of side effects, consult the official medication website, your healthcare provider, or pharmacist. Suspected side effects can be reported to the FDA.