US pharmacy pricing
Where to Find the Cheapest Orfadin Price
Lowest price found · US pharmacies
$3,843.75/fill
for Nitisinone, across the pharmacies in our data
Discount card
$3,843.75
per fill
Lowest listed pharmacy price
Cost Plus Drugs
$22.81
per unit
Published price, no card needed
US pharmacy prices — 20mg
| Pharmacy | Discount-card price | Regular cash price | Average retail |
|---|---|---|---|
| $3,843.75Lowest | $3,846.75 | $2,946.19 | |
| $11,546.12 | $11,549.12 | $2,946.19 | |
| $11,674.16 | $11,674.16 | $2,946.19 | |
| $13,076.10 | $13,076.10 | $2,946.19 | |
| $17,655.93 | $17,658.93 | $2,946.19 | |
| $17,655.93 | $17,658.93 | $2,946.19 |
"Discount-card price" reflects a standard prescription discount card, not insurance. Prices change often — confirm at the pharmacy before filling.
Interchangeable forms
Per RxNorm (U.S. National Library of Medicine), these share the same active ingredient and strength as Nitisinone.
Frequently asked questions
Is Nitisinone (Orfadin) expensive if I don't have insurance?
At the US pharmacies in our data, the lowest listed discount-card price for Nitisinone is around $3,843.75. Prices vary by pharmacy, dosage, and pack size, so use the table above to compare specific options near you.
Can I buy Nitisinone (Orfadin) at a Cost Plus Drugs price?
Yes — Cost Plus Drugs lists Nitisinone at roughly $22.81 per unit, a published price with no membership card or coupon involved. See the three-price comparison above for how that stacks up against discount-card pharmacies.
Is a generic version of Nitisinone available?
Generic and brand-name pricing for Nitisinone is broken out in the tables above where both exist in our data. Generic versions are typically the lower-cost option, but availability depends on the specific formulation and dosage.
What can I expect to pay for Orfadin with insurance?
The cost of Orfadin with insurance depends entirely on your specific plan's formulary, copay, deductible, and coinsurance structure. Coverage is not guaranteed, so you must contact your insurance provider directly for details on your out-of-pocket responsibility. If your plan does not cover Orfadin, or if you are enrolled in Medicare or Medicaid and the medication is not on their approved list, you may still have options. Prescription discount programs are widely accepted and can be used to obtain a lower cash price at most pharmacies, often providing an alternative way to save. It can be helpful to compare the price available through such a program with your insurance copay to find the most affordable option.
Is a generic version of Orfadin available?
No, a generic equivalent for Orfadin is not currently available. Orfadin remains a brand-name medication manufactured by Sobi Ab. Patients prescribed this drug do not have a lower-cost generic alternative at this time.