US pharmacy pricing
Otrexup Prices at US Pharmacies
Lowest price found · US pharmacies
$1,590.76/fill
for Otrexup, across the pharmacies in our data
US pharmacy prices — 0.4ml of 12.5mg/0.4ml
| Pharmacy | Discount-card price | Regular cash price | Average retail |
|---|---|---|---|
 Kroger Pharmacy | $1,590.76Lowest | $1,593.76 | $2,363.82 |
 Harris Teeter Pharmacy | $1,590.76Lowest | $1,593.76 | $2,363.82 |
 CVS Pharmacy | $1,667.41 | $1,670.41 | $2,363.82 |
 Publix | $1,681.48 | $1,684.48 | $2,363.82 |
 Walmart Neighborhood Market | $1,708.23 | $1,711.23 | $2,363.82 |
 Walmart Pharmacy | $1,708.23 | $1,711.23 | $2,363.82 |
 Costco | $1,717.47 | $1,720.47 | $2,363.82 |
 Walgreens | $2,040.40 | $2,043.40 | $2,363.82 |
"Discount-card price" reflects a standard prescription discount card, not insurance. Prices change often — confirm at the pharmacy before filling.
Interchangeable forms
Per RxNorm (U.S. National Library of Medicine), these share the same active ingredient and strength as Otrexup.
Frequently asked questions
How much does Otrexup (Otrexup) cost without insurance?
At the US pharmacies in our data, the lowest listed discount-card price for Otrexup is around $1,590.76. Prices vary by pharmacy, dosage, and pack size, so use the table above to compare specific options near you.
Is a generic version of Otrexup available?
Generic and brand-name pricing for Otrexup is broken out in the tables above where both exist in our data. Generic versions are typically the lower-cost option, but availability depends on the specific formulation and dosage.
How much does Otrexup typically cost with insurance coverage?
Your out-of-pocket cost for Otrexup with insurance depends entirely on your specific plan's formulary and copay structure. It can vary widely. To ensure you are paying the lowest possible price, ask your pharmacist to compare your insurance copay against the price available through a pharmacy savings program. In many cases, a discount card may offer a lower price than your insurance copay.
Is there a generic version available for Otrexup?
Otrexup is a brand-name formulation of the drug methotrexate, delivered via a pre-filled auto-injector pen. Methotrexate injection solution is available as a generic from several manufacturers, including Mylan, West-Ward, and Hikma. Another brand-name version of injectable methotrexate is called Rasuvo. It's important to discuss formulation and delivery options with your doctor, as not all versions are interchangeable.
What is Otrexup, and how is it used?
Otrexup is a once-weekly subcutaneous injection prescribed for rheumatoid arthritis, polyarticular juvenile idiopathic arthritis, or severe psoriasis when other treatments have failed. It contains methotrexate, which helps modulate an overactive immune system that attacks the body's own tissues. The injection is administered under the skin of the abdomen or thigh. Strict adherence to the once-weekly schedule is critical. Important precautions include avoiding alcohol to reduce liver risk, limiting sun exposure, and not receiving live vaccines. You should also inform your doctor of all medications and medical conditions, and avoid driving until you know how the medication affects you. Otrexup must be stored safely away from children and pets.