Spironolactone-Hctz (Spironolactone-Hctz) Rx Price Comparison: US vs Canada — Save Up to 30% in Canada

Our most recent US pharmacy data shows a low of roughly $37.44 for Spironolactone-Hctz with a standard discount card. That figure moves with dosage and quantity — check the comparison table for the exact combination you need.

Yes — Cost Plus Drugs lists Spironolactone-Hctz at roughly $0.400 per unit, a published price with no membership card or coupon involved. See the three-price comparison above for how that stacks up against discount-card pharmacies.

We found Canadian pricing for Spironolactone-Hctz starting near $0.280 per tablet in USD terms. That's before any shipping charge, which the table above breaks out separately.

Drug pricing is set separately in each country through different negotiation, regulatory, and distribution systems, so the same medication can legitimately carry different price tags on either side of the border. In this case, our data shows the Canadian price coming in lower — but that isn't true for every drug, so it's worth checking each medication individually rather than assuming.

Spironolactone-HCTZ is the generic form of the prescription drug. It is manufactured by several companies, including Greenstone, Sun, Mylan, Apotex, and Teva. The original, brand-name version of this combination medication is called Aldactazide, which is produced by Pfizer. Brand-name drugs are typically more expensive than their generic counterparts.

Spironolactone-HCTZ is a combination diuretic medication prescribed to treat high blood pressure and edema (fluid retention) associated with conditions like heart, liver, or kidney failure, or when other diuretics have been ineffective. It contains two active ingredients: hydrochlorothiazide, a thiazide diuretic, and spironolactone, a potassium-sparing diuretic. Hydrochlorothiazide helps the kidneys eliminate excess salt and water. Spironolactone also promotes fluid loss but works in a different part of the kidney to help the body retain potassium. Used together, they provide effective fluid reduction while helping to mitigate the potassium loss that can occur with thiazide diuretics alone. The medication is usually taken once daily as a tablet, with the specific dosage determined by a doctor based on the patient's response and tolerance.

As with any medication, side effects vary; some people experience none, while others may have mild to serious reactions. Common side effects include lightheadedness, dizziness, drowsiness, fatigue, headache, decreased appetite, stomach discomfort, and gas. More serious risks involve electrolyte imbalances, such as low potassium or sodium levels, and dehydration—symptoms of which can include extreme thirst, dry mouth, muscle cramps, severe dizziness, and confusion. Although rare, severe allergic reactions are possible, manifesting as hives, difficulty breathing, swelling of the face, fever, sore throat, or severe skin rashes with blistering or peeling. This is not an exhaustive list. It is essential to discuss potential side effects with your healthcare provider or pharmacist before starting this medication and to seek immediate medical attention for any signs of a serious reaction.