Treximet (Sumatriptan-Naproxen Sodium) Rx Price Comparison: US vs Canada — Save Up to 12% in the US

Our most recent US pharmacy data shows a low of roughly $125.74 for Sumatriptan-Naproxen Sodium with a standard discount card. That figure moves with dosage and quantity — check the comparison table for the exact combination you need.

Yes — Cost Plus Drugs lists Sumatriptan-Naproxen Sodium at roughly $6.56 per unit, a published price with no membership card or coupon involved. See the three-price comparison above for how that stacks up against discount-card pharmacies.

We found Canadian pricing for Sumatriptan-Naproxen Sodium starting near $7.43 per tablet in USD terms. That's before any shipping charge, which the table above breaks out separately.

Drug pricing is set separately in each country through different negotiation, regulatory, and distribution systems, so the same medication can legitimately carry different price tags on either side of the border. In this case, our data shows the US price is actually the lower of the two once a program like Cost Plus Drugs is factored in — the assumption that Canada is always cheaper doesn't hold for every drug.

Yes. The brand-name drug Treximet, manufactured by Currax Pharmaceuticals, has a generic equivalent. The generic medication is called naproxen-sumatriptan.

Treximet is a combination medication used for the acute treatment of migraine attacks with or without aura. It is not intended for preventing migraines or for treating other headache types like hemiplegic or basilar migraines. The drug contains two active ingredients: sumatriptan and naproxen. Sumatriptan belongs to a class called triptans; it is believed to relieve migraine symptoms by constricting blood vessels in the brain and blocking pain pathways. Naproxen is an NSAID (nonsteroidal anti-inflammatory drug) that reduces inflammation and pain by inhibiting prostaglandin production. Treximet is taken at the first sign of a migraine to reduce symptoms, but it does not decrease the frequency of future headaches. It is contraindicated for individuals with uncontrolled high blood pressure, certain heart or circulatory conditions, severe liver disease, a history of allergic reaction to NSAIDs or aspirin, or those in the third trimester of pregnancy.

Common side effects of Treximet can include dizziness, drowsiness, weakness, muscle tightness, neck/jaw/chest discomfort, nausea, heartburn, tingling sensations, flushing, or heart palpitations. You should stop taking the medication and seek immediate medical attention if you experience symptoms such as severe stomach pain, black/tarry stools, vomiting blood, yellowing of the skin or eyes, unusual weight gain, extreme fatigue, flu-like symptoms, itching, diarrhea, swelling, or pain in the upper right abdomen. This list is not exhaustive. Always discuss potential side effects and drug interactions with your doctor or pharmacist before starting any new medication.