US pharmacy pricing
Symproic Cost Without Insurance — US Pharmacy Price Guide
Lowest price found · US pharmacies
$466.20/fill
for Symproic, across the pharmacies in our data
US pharmacy prices — 0.2mg
| Pharmacy | Discount-card price | Regular cash price | Average retail |
|---|---|---|---|
 Kroger Pharmacy | $466.20Lowest | $469.20 | $41.49 |
 Harris Teeter Pharmacy | $466.20Lowest | $469.20 | $41.49 |
 Walgreens | $487.39 | $490.39 | $41.49 |
 Publix | $491.70 | $494.70 | $41.49 |
 Walmart Neighborhood Market | $498.39 | $501.39 | $41.49 |
 Walmart Pharmacy | $498.39 | $501.39 | $41.49 |
 CVS Pharmacy | $498.46 | $501.46 | $41.49 |
 Costco | $500.94 | $503.94 | $41.49 |
 Food Lion | $528.39 | $528.39 | $41.49 |
"Discount-card price" reflects a standard prescription discount card, not insurance. Prices change often — confirm at the pharmacy before filling.
Interchangeable forms
Per RxNorm (U.S. National Library of Medicine), these share the same active ingredient and strength as Symproic.
Frequently asked questions
What's the cash price for Symproic (Symproic) in the US?
Our most recent US pharmacy data shows a low of roughly $466.20 for Symproic with a standard discount card. That figure moves with dosage and quantity — check the comparison table for the exact combination you need.
Does Symproic have a generic equivalent?
Generic and brand-name pricing for Symproic is broken out in the tables above where both exist in our data. Generic versions are typically the lower-cost option, but availability depends on the specific formulation and dosage.
Is Symproic covered by Medicare, and what would it cost?
Coverage for Symproic under Medicare Part D plans is not guaranteed and varies by plan. You should check your plan's formulary to see if it is a covered medication. For out-of-pocket costs, you may be able to use a prescription savings card, which is accepted at many major pharmacy chains, to obtain a lower price.
Is a generic form of Symproic available?
No, Symproic is only available as a brand-name medication; there is no FDA-approved generic equivalent in the U.S. market. Other brand-name drugs with a similar mechanism of action for treating OIC include Relistor (methylnaltrexone) and Movantik (naloxegol). Your healthcare provider can determine which medication is appropriate for your condition. Savings on brand-name prescriptions like these may be available through various pharmacy discount programs.
What is Symproic used for, and what should I know before taking it?
Symproic (naldemedine) is an FDA-approved opioid antagonist prescribed specifically for opioid-induced constipation in adults with chronic, non-cancer pain. It is not approved for use in children under 18. Important safety information includes warnings against use if you have a known allergy to naldemedine, a bowel blockage, stomach ulcer, or significant liver disease. Inform your doctor of all your medical conditions and medications, including over-the-counter products and supplements, to avoid interactions. Symproic can cause opioid withdrawal symptoms; it should not be used during pregnancy or breastfeeding due to potential risks to the baby. Take it exactly as prescribed, and note that it may be less effective if you have been on opioid therapy for less than four weeks.