US pharmacy pricing
Syprine Cost Without Insurance — US Pharmacy Price Guide
Lowest price found · US pharmacies
$245.75/fill
for Trientine Hcl, across the pharmacies in our data
Discount card
$245.75
per fill
Lowest listed pharmacy price
Cost Plus Drugs
$1.76
per unit
Published price, no card needed
US pharmacy prices — 250mg
| Pharmacy | Discount-card price | Regular cash price | Average retail |
|---|---|---|---|
 Walgreens | $245.75Lowest | $248.75 | $1,765.99 |
 Food Lion | $1,012.30 | $1,012.30 | $1,765.99 |
 Costco | $5,709.49 | $5,709.49 | $1,765.99 |
 Publix | $11,264.64 | $11,267.64 | $1,765.99 |
 Kroger Pharmacy | $17,207.86 | $17,210.86 | $1,765.99 |
 Harris Teeter Pharmacy | $17,207.86 | $17,210.86 | $1,765.99 |
"Discount-card price" reflects a standard prescription discount card, not insurance. Prices change often — confirm at the pharmacy before filling.
Interchangeable forms
Per RxNorm (U.S. National Library of Medicine), these share the same active ingredient and strength as Trientine Hcl.
Frequently asked questions
How much does Trientine Hcl (Syprine) cost without insurance?
Our most recent US pharmacy data shows a low of roughly $245.75 for Trientine Hcl with a standard discount card. That figure moves with dosage and quantity — check the comparison table for the exact combination you need.
Is Trientine Hcl (Syprine) available through Cost Plus Drugs?
Yes — Cost Plus Drugs lists Trientine Hcl at roughly $1.76 per unit, a published price with no membership card or coupon involved. See the three-price comparison above for how that stacks up against discount-card pharmacies.
Does Trientine Hcl have a generic equivalent?
Generic and brand-name pricing for Trientine Hcl is broken out in the tables above where both exist in our data. Generic versions are typically the lower-cost option, but availability depends on the specific formulation and dosage.
How does insurance affect the cost of Syprine?
Your out-of-pocket cost for Syprine with insurance depends entirely on your specific plan's formulary and copay structure. In some cases, the price you pay with a prescription savings coupon or card may be lower than your insurance copay. It's recommended to ask your pharmacist to compare the price under your insurance versus other available savings options to ensure you get the lowest possible price.
Is Syprine covered by Medicare, and what are the costs?
Syprine is infrequently covered by Medicare Part D or Medicare Advantage prescription drug plans. These plans more commonly cover the generic version, trientine. For patients without coverage, prescription discount programs may offer savings. It's important to check your plan's formulary and discuss alternative savings options with your pharmacist.
Is a generic version of Syprine available?
Yes. Syprine is the brand name for the drug trientine. Generic trientine is widely available and manufactured by several companies, including Novadoz, Dr. Reddy's, and Amneal. Generic medications typically cost less than the brand-name version. Information on pricing and potential savings for generic trientine can be found through many pharmacy websites and prescription savings resources.