Fluorouracil (Fluorouracil) Rx Price Comparison: US vs Canada — Save Up to 93% in Canada

At the US pharmacies in our data, the lowest listed discount-card price for Fluorouracil is around $32.96. Prices vary by pharmacy, dosage, and pack size, so use the table above to compare specific options near you.

Yes — Cost Plus Drugs lists Fluorouracil at roughly $10.00 per unit, a published price with no membership card or coupon involved. See the three-price comparison above for how that stacks up against discount-card pharmacies.

Canadian pharmacy listings in our data show Fluorouracil priced from about $0.730 per tablet (converted to USD), before shipping. Pack size and pharmacy both affect the final total — see the Canada pricing table for specifics.

Drug pricing is set separately in each country through different negotiation, regulatory, and distribution systems, so the same medication can legitimately carry different price tags on either side of the border. In this case, our data shows the Canadian price coming in lower — but that isn't true for every drug, so it's worth checking each medication individually rather than assuming.

Yes. Fluorouracil is the generic name for this medication. It is also sold under several brand names, including Efudex, Carac, and Adrucil.

Fluorouracil is a prescription topical medication approved by the FDA to treat actinic keratosis (precancerous skin growths) and certain types of superficial skin cancer. It is classified as an antimetabolite and works by interfering with the growth of abnormal skin cells. Your doctor will provide specific instructions for use based on your condition. Typically, you should apply it to clean, dry skin in a thin layer, washing your hands thoroughly afterward. The treated skin area often becomes red, irritated, and unsightly during therapy, which can last for several weeks. Do not use tight bandages over the area unless your doctor advises you to use a loose gauze dressing. Always use exactly as prescribed and consult your healthcare provider with any questions.

The most frequent side effects are localized skin reactions at the application site, including burning, pain, redness, swelling, dryness, tenderness, irritation, and changes in skin color. Some people may also experience eye irritation if the medication comes into contact with the eyes, temporary hair loss in the treated area, or trouble sleeping. These effects are often expected signs that the medication is working but can be uncomfortable. Contact your doctor or pharmacist if these reactions become severe or worsen. This is not a complete list of possible side effects, so discuss the full risks and benefits of treatment with your healthcare provider.