US pharmacy pricing
Trifluridine Cost Without Insurance — US Pharmacy Price Guide
Lowest price found · US pharmacies
$201.68/fill
for Trifluridine, across the pharmacies in our data
Discount card
$201.68
per fill
Lowest listed pharmacy price
Cost Plus Drugs
$178.98
per unit
Published price, no card needed
US pharmacy prices — 1%
| Pharmacy | Discount-card price | Regular cash price | Average retail |
|---|---|---|---|
 Kroger Pharmacy | $201.68Lowest | $204.68 | $30.41 |
 Harris Teeter Pharmacy | $201.68Lowest | $204.68 | $30.41 |
 Walgreens | $213.23 | $216.23 | $30.41 |
 Publix | $215.71 | $218.71 | $30.41 |
 Food Lion | $216.26 | $216.26 | $30.41 |
 Walmart Neighborhood Market | $216.89 | $219.89 | $30.41 |
 Walmart Pharmacy | $216.89 | $219.89 | $30.41 |
 CVS Pharmacy | $219.92 | $222.92 | $30.41 |
 Costco | $232.76 | $232.76 | $30.41 |
"Discount-card price" reflects a standard prescription discount card, not insurance. Prices change often — confirm at the pharmacy before filling.
Interchangeable forms
Per RxNorm (U.S. National Library of Medicine), these share the same active ingredient and strength as Trifluridine.
Frequently asked questions
What's the cash price for Trifluridine in the US?
Our most recent US pharmacy data shows a low of roughly $201.68 for Trifluridine with a standard discount card. That figure moves with dosage and quantity — check the comparison table for the exact combination you need.
Is Trifluridine available through Cost Plus Drugs?
Yes — Cost Plus Drugs lists Trifluridine at roughly $178.98 per unit, a published price with no membership card or coupon involved. See the three-price comparison above for how that stacks up against discount-card pharmacies.
Does Trifluridine have a generic equivalent?
Generic and brand-name pricing for Trifluridine is broken out in the tables above where both exist in our data. Generic versions are typically the lower-cost option, but availability depends on the specific formulation and dosage.
What is the brand-name equivalent of Trifluridine?
Trifluridine is the generic name for the active ingredient found in the brand-name prescription eye drops called Viroptic. The generic version is manufactured by several pharmaceutical companies, including Hi-Tech, Sandoz, and Apotex. You can search for cost information and potential savings offers for both Viroptic and trifluridine through various pharmacy resources and discount program websites.
What is Trifluridine and how does it work?
Trifluridine is a prescription antiviral eye drop specifically formulated to treat infections of the eye caused by the herpes simplex virus. Ocular herpes is a recurrent infection that can be challenging to manage and may lead to inflammation, ulcers on the eyelids, or damage to the cornea. It is important to note that trifluridine is only effective against herpes simplex virus infections and will not treat bacterial or fungal eye infections. As a nucleoside analogue, its mechanism of action involves integrating into the viral DNA to halt the replication process of the virus.
What side effects are associated with Trifluridine?
The most frequently reported side effects of trifluridine are local reactions at the application site, such as transient burning, stinging, irritation, or mild swelling upon instilling the drops. Serious allergic reactions are uncommon but can occur; symptoms may include hives, facial swelling, or difficulty breathing, which require immediate emergency medical care. This list is not exhaustive, so it's essential to discuss any concerns or unexpected symptoms with your prescribing doctor.