US pharmacy pricing
Yupelri Cost Without Insurance — US Pharmacy Price Guide
Lowest price found · US pharmacies
$54.55/fill
for Yupelri, across the pharmacies in our data
US pharmacy prices — 3ml of 175mcg/3ml
| Pharmacy | Discount-card price | Regular cash price | Average retail |
|---|---|---|---|
 Kroger Pharmacy | $54.55Lowest | $57.55 | $85.64 |
 Harris Teeter Pharmacy | $54.55Lowest | $57.55 | $85.64 |
 Costco | $58.86 | $61.86 | $85.64 |
 Walgreens | $58.95 | $61.95 | $85.64 |
 Walmart Neighborhood Market | $59.04 | $62.04 | $85.64 |
 Walmart Pharmacy | $59.04 | $62.04 | $85.64 |
 Publix | $60.53 | $63.53 | $85.64 |
 CVS Pharmacy | $75.80 | $78.80 | $85.64 |
"Discount-card price" reflects a standard prescription discount card, not insurance. Prices change often — confirm at the pharmacy before filling.
Interchangeable forms
Per RxNorm (U.S. National Library of Medicine), these share the same active ingredient and strength as Yupelri.
Frequently asked questions
Is Yupelri (Yupelri) expensive if I don't have insurance?
Our most recent US pharmacy data shows a low of roughly $54.55 for Yupelri with a standard discount card. That figure moves with dosage and quantity — check the comparison table for the exact combination you need.
Does Yupelri have a generic equivalent?
Generic and brand-name pricing for Yupelri is broken out in the tables above where both exist in our data. Generic versions are typically the lower-cost option, but availability depends on the specific formulation and dosage.
Is a generic version of Yupelri available?
No, a generic version of Yupelri is not currently on the market. Yupelri is the brand-name product containing the active ingredient revefenacin. Patients must use the brand-name medication until a generic equivalent receives FDA approval.
What is Yupelri and how does it work?
Yupelri is a prescription bronchodilator used for the daily maintenance treatment of COPD, a chronic lung disease that causes breathing difficulties. Its active ingredient, revefenacin, is a long-acting anticholinergic. It works by blocking acetylcholine, a chemical messenger that signals airway muscles to tighten. By preventing this constriction, Yupelri helps keep the airways relaxed and open for about 24 hours, making breathing easier. It is important to note that Yupelri is for routine management, not for treating sudden breathing problems (rescue therapy). The medication is taken once daily using a specific type of jet nebulizer with a compressor and mouthpiece.
What side effects are associated with Yupelri?
Common side effects of Yupelri often relate to the inhalation process and may include cough, runny nose, sore throat, mouth pain, and bronchitis. Other frequently reported effects are upper respiratory tract infections, headache, back pain, and dizziness. More serious, though less common, potential side effects include increased blood pressure, sudden airway constriction (bronchospasm), and worsening of glaucoma. Allergic reactions are rare but require immediate medical attention. If you experience signs of an allergic reaction or difficulty breathing right after using Yupelri, stop the medication and contact your doctor promptly.