Full price comparison · US & Canada
Depakote (Divalproex Sodium Er) Rx Price Comparison: US vs Canada — Save Up to 95% in the US
Cheaper in the US
0%
lower price for Divalproex Sodium Er, based on the lowest comparable per-unit prices we found
US · discount card
$21.20
per fill
Lowest listed pharmacy price
US · Cost Plus Drugs
$0.030
per unit
Published price, no card needed
Canada
$0.560
per tablet
Lowest listed pharmacy price
US pharmacy prices — 250mg
| Pharmacy | Discount-card price | Regular cash price | Average retail |
|---|---|---|---|
 Food Lion | $21.20Lowest | $21.20 | $11.99 |
 Walmart Neighborhood Market | $22.16 | $25.16 | $11.99 |
 Walmart Pharmacy | $22.16 | $25.16 | $11.99 |
 Walgreens | $22.98 | $25.98 | $11.99 |
 Costco | $25.25 | $25.25 | $11.99 |
 CVS Pharmacy | $26.73 | $29.73 | $11.99 |
 Kroger Pharmacy | $26.77 | $29.77 | $11.99 |
 Harris Teeter Pharmacy | $26.77 | $29.77 | $11.99 |
 Publix | $28.56 | $28.56 | $11.99 |
"Discount-card price" reflects a standard prescription discount card, not insurance. Prices change often — confirm at the pharmacy before filling.
Canadian pharmacy prices
Initial · 500 mg
| Pharmacy | Price / tablet | Pack size | Shipping | Total |
|---|---|---|---|---|
 CanadianPrescriptionDrugstore.com | $0.560 | 90 | $14.95 | $50.00Lowest |
 InhalersOnline.com | $0.820 | — | $0.00 | $123.20 |
| InhalersOnline.com | $2.86 | — | $0.00 | $42.85 |
Canadian prices are converted to USD at the time of listing and shown before any duties. Shipping and delivery times vary by pharmacy.
Interchangeable forms
Per RxNorm (U.S. National Library of Medicine), these share the same active ingredient and strength as Divalproex Sodium Er.
Frequently asked questions
Is Divalproex Sodium Er (Depakote) expensive if I don't have insurance?
Our most recent US pharmacy data shows a low of roughly $21.20 for Divalproex Sodium Er with a standard discount card. That figure moves with dosage and quantity — check the comparison table for the exact combination you need.
Is Divalproex Sodium Er (Depakote) available through Cost Plus Drugs?
Yes — Cost Plus Drugs lists Divalproex Sodium Er at roughly $0.030 per unit, a published price with no membership card or coupon involved. See the three-price comparison above for how that stacks up against discount-card pharmacies.
What do Canadian pharmacies charge for Divalproex Sodium Er (Depakote)?
We found Canadian pricing for Divalproex Sodium Er starting near $0.560 per tablet in USD terms. That's before any shipping charge, which the table above breaks out separately.
Why is Divalproex Sodium Er (Depakote) priced differently in the US and Canada?
Drug pricing is set separately in each country through different negotiation, regulatory, and distribution systems, so the same medication can legitimately carry different price tags on either side of the border. In this case, our data shows the US price is actually the lower of the two once a program like Cost Plus Drugs is factored in — the assumption that Canada is always cheaper doesn't hold for every drug.
Is a generic form of Depakote ER available?
Yes. Depakote ER is the brand-name version of divalproex sodium extended-release, manufactured by AbbVie Inc. The generic equivalent is available.
What is Depakote ER used to treat?
Depakote ER is an extended-release anticonvulsant from the fatty acid derivative drug class. It is primarily prescribed to treat various types of seizure disorders, manage manic episodes in bipolar disorder, and help prevent migraine headaches. The medication works by helping to restore the balance of certain neurotransmitters in the brain. It is crucial to discuss your full medical history with your doctor before starting this medication, as it is contraindicated in people with certain liver diseases, urea cycle disorders, or specific genetic conditions like Alpers' disease. Special precautions are necessary for individuals with a history of depression, mental illness, or mitochondrial disorders. Due to a high risk of serious birth defects and potential long-term effects on a child's development, the use of Depakote ER during pregnancy requires careful management and should never be started or stopped without direct medical supervision.
What side effects are associated with Depakote ER?
Common side effects of Depakote ER can include nausea, vomiting, stomach discomfort, diarrhea, headache, dizziness, weakness, tremors, coordination problems, blurred vision, and changes in appetite or weight. A serious and potentially fatal risk is liver failure, which is of particular concern for children under two years old and individuals with certain genetic mitochondrial disorders. This is not a complete list of possible adverse effects. Always consult your healthcare provider for advice on managing any side effects you experience.