US pharmacy pricing
Opsumit Prices at US Pharmacies
Lowest price found · US pharmacies
$4,606.35/fill
for Macitentan, across the pharmacies in our data
Discount card
$4,606.35
per fill
Lowest listed pharmacy price
Cost Plus Drugs
$1.67
per unit
Published price, no card needed
US pharmacy prices — 10mg
| Pharmacy | Discount-card price | Regular cash price | Average retail |
|---|---|---|---|
 Walgreens | $4,606.35Lowest | $4,609.35 | $14,533.13 |
 Publix | $7,059.23 | $7,062.23 | $25,175.48 |
 Kroger Pharmacy | $10,788.25 | $10,791.25 | $14,533.13 |
 Harris Teeter Pharmacy | $10,788.25 | $10,791.25 | $14,533.13 |
 Walmart Neighborhood Market | $11,510.50 | $11,513.50 | $14,533.13 |
 Walmart Pharmacy | $11,510.50 | $11,513.50 | $14,533.13 |
 Food Lion | $11,514.50 | $11,514.50 | $25,175.48 |
 Costco | $11,516.50 | $11,516.50 | $25,175.48 |
"Discount-card price" reflects a standard prescription discount card, not insurance. Prices change often — confirm at the pharmacy before filling.
Interchangeable forms
Per RxNorm (U.S. National Library of Medicine), these share the same active ingredient and strength as Macitentan.
Frequently asked questions
Is Macitentan (Opsumit) expensive if I don't have insurance?
At the US pharmacies in our data, the lowest listed discount-card price for Macitentan is around $4,606.35. Prices vary by pharmacy, dosage, and pack size, so use the table above to compare specific options near you.
Can I buy Macitentan (Opsumit) at a Cost Plus Drugs price?
Yes — Cost Plus Drugs lists Macitentan at roughly $1.67 per unit, a published price with no membership card or coupon involved. See the three-price comparison above for how that stacks up against discount-card pharmacies.
Is a generic version of Macitentan available?
Generic and brand-name pricing for Macitentan is broken out in the tables above where both exist in our data. Generic versions are typically the lower-cost option, but availability depends on the specific formulation and dosage.
How much can I expect to pay for Opsumit with insurance?
Even with insurance, copayments for Opsumit can vary widely and may still be substantial due to the drug's high price. The amount you pay depends on your specific plan's formulary and coverage tier. It is highly recommended to ask your case manager or the pharmacist at the certified REMS pharmacy to provide a cost comparison between your insurance copay and the price available through any pharmacy discount programs you may qualify for.
Is Opsumit covered by Medicare, and what are the costs?
Opsumit is typically covered under Medicare Part D and Medicare Advantage plans, but patient cost-sharing (like copays or coinsurance) can be significant. For female patients, the medication is dispensed exclusively through certified REMS pharmacies. When discussing your prescription, speak with the pharmacy's pharmacist or case manager. They can review your Medicare plan details and also inform you about any available savings options that could help manage your out-of-pocket expenses.
Is a generic version of Opsumit available?
No. Opsumit is currently only available as a brand-name medication, and no generic (bioequivalent) alternatives are on the market.