US pharmacy pricing
Prolia Cost Without Insurance — US Pharmacy Price Guide
Lowest price found · US pharmacies
$1,891.19/fill
for Prolia, across the pharmacies in our data
US pharmacy prices — 1ml of 60mg/ml
| Pharmacy | Discount-card price | Regular cash price | Average retail |
|---|---|---|---|
 Kroger Pharmacy | $1,891.19Lowest | $1,894.19 | $2,302.96 |
 Harris Teeter Pharmacy | $1,891.19Lowest | $1,894.19 | $2,302.96 |
 Walgreens | $1,985.67 | $1,988.67 | $2,302.96 |
 Publix | $2,001.51 | $2,001.51 | $2,302.96 |
 Costco | $2,041.87 | $2,044.87 | $2,302.96 |
"Discount-card price" reflects a standard prescription discount card, not insurance. Prices change often — confirm at the pharmacy before filling.
Interchangeable forms
Per RxNorm (U.S. National Library of Medicine), these share the same active ingredient and strength as Prolia.
Frequently asked questions
How much does Prolia (Prolia) cost without insurance?
At the US pharmacies in our data, the lowest listed discount-card price for Prolia is around $1,891.19. Prices vary by pharmacy, dosage, and pack size, so use the table above to compare specific options near you.
Is a generic version of Prolia available?
Generic and brand-name pricing for Prolia is broken out in the tables above where both exist in our data. Generic versions are typically the lower-cost option, but availability depends on the specific formulation and dosage.
Is a generic version of Prolia available?
No, Prolia is a brand-name biologic medication, and a generic (biosimilar) equivalent is not currently available in the United States.
What is Prolia and how does it work?
Prolia is an FDA-approved prescription injection containing the active ingredient denosumab. It is primarily used to treat osteoporosis in postmenopausal women who are at an increased risk for fractures. Osteoporosis is a condition characterized by weakened bones that are more prone to breaking. Prolia works by binding to and inhibiting a protein called RANK ligand. This action slows the activity of bone-resorbing cells (osteoclasts), which helps to increase bone density and strength over time. The injection is typically administered by a healthcare professional under the skin (subcutaneously) in the arm, thigh, or abdomen once every six months. Treatment is often supplemented with adequate calcium and vitamin D to support bone health.
What are the potential side effects of Prolia?
Prolia can cause a decrease in blood calcium levels (hypocalcemia), particularly in patients with kidney impairment. To mitigate this, doctors often recommend calcium and vitamin D supplements and may monitor blood calcium levels before and during treatment. Symptoms of low calcium include muscle spasms, numbness, tingling, mood changes, irregular heartbeat, and severe dizziness, which require immediate medical attention. Because Prolia can suppress the immune system, there is an increased risk of serious infections, such as those of the skin, bladder, or ears. Patients should alert their doctor if they experience signs of infection like fever, chills, persistent back or abdominal pain, or swollen skin. This list is not exhaustive, and other side effects may occur. Always discuss the full benefits and risks with your healthcare provider before starting treatment.