US pharmacy pricing
Xgeva Cost Without Insurance — US Pharmacy Price Guide
Lowest price found · US pharmacies
$3,477.06/fill
for Xgeva, across the pharmacies in our data
US pharmacy prices — 1.7ml of 120mg/1.7ml
| Pharmacy | Discount-card price | Regular cash price | Average retail |
|---|---|---|---|
 Kroger Pharmacy | $3,477.06Lowest | $3,480.06 | $4,284.16 |
 Harris Teeter Pharmacy | $3,477.06Lowest | $3,480.06 | $4,284.16 |
 Walgreens | $3,649.37 | $3,652.37 | $4,284.16 |
 Publix | $3,674.94 | $3,674.94 | $4,284.16 |
 Costco | $3,754.21 | $3,757.21 | $4,284.16 |
"Discount-card price" reflects a standard prescription discount card, not insurance. Prices change often — confirm at the pharmacy before filling.
Interchangeable forms
Per RxNorm (U.S. National Library of Medicine), these share the same active ingredient and strength as Xgeva.
Frequently asked questions
How much does Xgeva (Xgeva) cost without insurance?
At the US pharmacies in our data, the lowest listed discount-card price for Xgeva is around $3,477.06. Prices vary by pharmacy, dosage, and pack size, so use the table above to compare specific options near you.
Is a generic version of Xgeva available?
Generic and brand-name pricing for Xgeva is broken out in the tables above where both exist in our data. Generic versions are typically the lower-cost option, but availability depends on the specific formulation and dosage.
Is a generic version of Xgeva available?
No, Xgeva is currently only available as a brand-name medication. Its active ingredient is denosumab, and a generic equivalent is not on the market at this time.
What is Xgeva used to treat, and how does it work?
Xgeva is a brand-name drug prescribed to prevent skeletal-related events, such as fractures, in patients with bone metastases from solid tumors or multiple myeloma. It is also used to treat hypercalcemia of malignancy (high blood calcium caused by cancer). The medication contains the active agent denosumab, a monoclonal antibody that acts as a RANK ligand inhibitor. By binding to this protein, denosumab inhibits osteoclasts—the cells responsible for bone resorption—thereby slowing bone breakdown and the release of calcium into the bloodstream. Xgeva is administered as a subcutaneous injection, usually once every four weeks.
What are some potential side effects of Xgeva?
Common side effects can include reactions at the injection site (redness, pain), headache, fatigue, back or muscle pain, nausea, diarrhea, and joint pain. More serious but less common risks include osteonecrosis of the jaw (bone death in the jaw), atypical femur fractures, and hypocalcemia (low blood calcium), which can be severe. The medication can also cause fetal harm and is not recommended during pregnancy. Allergic reactions, though rare, are possible and may present with rash, facial swelling, or difficulty breathing. This is not an exhaustive list, so discussing all potential risks and side effects with your prescribing doctor is essential.