Symdeko Cost Without Insurance — US Pharmacy Price Guide

Our most recent US pharmacy data shows a low of roughly $24,898.25 for Symdeko with a standard discount card. That figure moves with dosage and quantity — check the comparison table for the exact combination you need.

Generic and brand-name pricing for Symdeko is broken out in the tables above where both exist in our data. Generic versions are typically the lower-cost option, but availability depends on the specific formulation and dosage.

No. Symdeko is a brand-name medication produced by Vertex Pharmaceuticals Incorporated. There is currently no FDA-approved generic equivalent available.

Symdeko is a prescription medication approved by the FDA to treat cystic fibrosis in adults and children aged six years and older. It combines two active ingredients, ivacaftor and tezacaftor, which work by helping regulate the balance of salt and water in organs like the lungs. This can lead to improved lung function, a reduced risk of infections, and better weight gain. The medication is typically taken as two different oral tablets daily—one in the morning and one in the evening, approximately twelve hours apart. Both doses should be taken with a fat-containing food, such as eggs, nuts, or cheese. Your doctor will determine the appropriate dosage based on your health status and other medications. Avoid grapefruit products while taking Symdeko unless your healthcare provider advises otherwise, as they can increase the risk of side effects. For the best results, take the medication consistently at the same times each day.

Common side effects of Symdeko can include headache, dizziness, and nausea. Inform your doctor if these effects are bothersome or persistent. Many people take this medication without experiencing serious problems, but it's important to be aware of potential risks. In rare cases, Symdeko may cause serious liver injury. Seek immediate medical attention if you develop symptoms such as persistent nausea, stomach pain, loss of appetite, yellowing of the skin or eyes, or dark urine. Severe allergic reactions are also uncommon but require urgent care. Watch for signs like rash, itching, swelling of the face or throat, severe dizziness, chest tightness, or difficulty breathing. This is not a complete list of all possible side effects. Your doctor or pharmacist can provide more detailed information about the risks and benefits of Symdeko for your specific situation.