Full price comparison · US & Canada
Effexor XR Prices — US Pharmacy Cost vs Canada — Save Up to 99% in the US
Cheaper in the US
0%
lower price for Venlafaxine Hcl Er, based on the lowest comparable per-unit prices we found
US · discount card
$6.46
per fill
Lowest listed pharmacy price
US · Cost Plus Drugs
$0.025
per unit
Published price, no card needed
Canada
$2.54
per tablet
Lowest listed pharmacy price
US pharmacy prices — 150mg
| Pharmacy | Discount-card price | Regular cash price | Average retail |
|---|---|---|---|
 Kroger Pharmacy | $6.46Lowest | $9.46 | $11.99 |
 Harris Teeter Pharmacy | $6.46Lowest | $9.46 | $11.99 |
 Food Lion | $12.64 | $12.64 | $11.99 |
 Walgreens | $13.88 | $16.88 | $11.99 |
 Walmart Neighborhood Market | $15.00 | $15.00 | $11.99 |
 Walmart Pharmacy | $15.00 | $15.00 | $11.99 |
 Publix | $21.46 | $21.46 | $11.99 |
 CVS Pharmacy | $23.04 | $26.04 | $11.99 |
 Costco | $25.99 | $25.99 | $11.99 |
"Discount-card price" reflects a standard prescription discount card, not insurance. Prices change often — confirm at the pharmacy before filling.
Canadian pharmacy prices
Initial · 225 mg
| Pharmacy | Price / tablet | Pack size | Shipping | Total |
|---|---|---|---|---|
 CanadianPrescriptionDrugstore.com | $2.54 | 84 | $14.95 | $213.00Lowest |
Canadian prices are converted to USD at the time of listing and shown before any duties. Shipping and delivery times vary by pharmacy.
Interchangeable forms
Per RxNorm (U.S. National Library of Medicine), these share the same active ingredient and strength as Venlafaxine Hcl Er.
Frequently asked questions
What's the cash price for Venlafaxine Hcl Er (Effexor XR) in the US?
Our most recent US pharmacy data shows a low of roughly $6.46 for Venlafaxine Hcl Er with a standard discount card. That figure moves with dosage and quantity — check the comparison table for the exact combination you need.
Is Venlafaxine Hcl Er (Effexor XR) available through Cost Plus Drugs?
Yes — Cost Plus Drugs lists Venlafaxine Hcl Er at roughly $0.025 per unit, a published price with no membership card or coupon involved. See the three-price comparison above for how that stacks up against discount-card pharmacies.
What do Canadian pharmacies charge for Venlafaxine Hcl Er (Effexor XR)?
We found Canadian pricing for Venlafaxine Hcl Er starting near $2.54 per tablet in USD terms. That's before any shipping charge, which the table above breaks out separately.
Why is Venlafaxine Hcl Er (Effexor XR) priced differently in the US and Canada?
Drug pricing is set separately in each country through different negotiation, regulatory, and distribution systems, so the same medication can legitimately carry different price tags on either side of the border. In this case, our data shows the US price is actually the lower of the two once a program like Cost Plus Drugs is factored in — the assumption that Canada is always cheaper doesn't hold for every drug.
What is the typical cost of Effexor XR without insurance?
For patients paying out of pocket, the retail price for brand-name Effexor XR can be substantial. However, the generic version, venlafaxine ER, is available at a much lower cost. Many pharmacies, including major chains, offer generic prescriptions at a significantly reduced price when using a prescription savings program.
How much will Effexor XR cost if I have insurance?
Your copay for Effexor XR depends on your specific insurance plan and its formulary. It's often beneficial to compare the price under your insurance with the cash price for the generic version using a pharmacy discount program. Your pharmacist can help you run this comparison at the point of sale to ensure you are paying the lowest possible price for your prescription.
Is Effexor XR covered by Medicare, and what are the costs?
Most Medicare Part D plans do not cover brand-name Effexor XR but typically do cover its generic counterpart, venlafaxine ER. For Medicare beneficiaries, opting for the generic and utilizing a pharmacy savings option can result in a much lower out-of-pocket cost. It's advisable to check your specific plan's formulary for precise coverage details.