US pharmacy pricing
Xerese Cost Without Insurance — US Pharmacy Price Guide
Lowest price found · US pharmacies
$1,322.73/fill
for Xerese, across the pharmacies in our data
US pharmacy prices — 5gm of 5-1%
| Pharmacy | Discount-card price | Regular cash price | Average retail |
|---|---|---|---|
 Kroger Pharmacy | $1,322.73Lowest | $1,325.73 | $321.99 |
 Harris Teeter Pharmacy | $1,322.73Lowest | $1,325.73 | $321.99 |
 Food Lion | $1,385.45 | $1,385.45 | $321.99 |
 Walgreens | $1,389.30 | $1,392.30 | $321.99 |
 CVS Pharmacy | $1,389.70 | $1,392.70 | $321.99 |
 Publix | $1,398.66 | $1,401.66 | $321.99 |
 Walmart Neighborhood Market | $1,420.47 | $1,423.47 | $321.99 |
 Walmart Pharmacy | $1,420.47 | $1,423.47 | $321.99 |
 Costco | $1,428.07 | $1,431.07 | $321.99 |
"Discount-card price" reflects a standard prescription discount card, not insurance. Prices change often — confirm at the pharmacy before filling.
Interchangeable forms
Per RxNorm (U.S. National Library of Medicine), these share the same active ingredient and strength as Xerese.
Frequently asked questions
What's the cash price for Xerese (Xerese) in the US?
Our most recent US pharmacy data shows a low of roughly $1,322.73 for Xerese with a standard discount card. That figure moves with dosage and quantity — check the comparison table for the exact combination you need.
Does Xerese have a generic equivalent?
Generic and brand-name pricing for Xerese is broken out in the tables above where both exist in our data. Generic versions are typically the lower-cost option, but availability depends on the specific formulation and dosage.
Is a generic version of Xerese available?
No. Xerese is a brand-name product manufactured by Bausch Health, and there is currently no FDA-approved generic equivalent on the market.
What is Xerese and how is it used?
Xerese is a combination topical cream containing acyclovir, an antiviral, and hydrocortisone, a corticosteroid. It is used to treat cold sores caused by the herpes simplex virus. The medication works by inhibiting viral replication while reducing inflammation, itching, pain, and burning associated with the sores. It can shorten healing time but does not cure the underlying herpes infection or prevent its transmission. For external use only, it should be applied at the first sign of an outbreak. Clean and dry the area first, then apply a thin layer to cover the affected skin, typically five times daily for up to five days. Avoid applying other skin products (like makeup or sunscreen) to the area and try to avoid washing or showering the area for at least 30 minutes after application to allow absorption. Take care to avoid contact with eyes, nose, mouth, or ears; if contact occurs, rinse thoroughly with water. Always use this medication exactly as directed by your healthcare provider.
What side effects are associated with Xerese?
Common side effects are typically local reactions at the application site, such as skin dryness or flaking, burning, stinging, redness, itching, or changes in skin color. These are often mild and temporary. Serious side effects are uncommon but can include allergic reactions. Seek immediate medical help if you experience symptoms like rash, hives, severe itching, swelling of the face or throat, trouble breathing, or intense dizziness. This is not a full list of possible effects or interactions. Discuss any persistent or concerning symptoms with your doctor or pharmacist, and report adverse reactions to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.